Here's how I decide the "best" cartridge rifle combination for me:
I go downstairs in a panic that deer season is a week away, find which rifle has the most ammunition available for which it was sighted in last time at the range, and go out two or three times to get some last minute practice, and that is what I take.
That being said, it is most likely a 7mm Remington Magnum, .30-06, .308, .270, and in Blackpowder season, the Knight .50 Disc Rifle. I really don't care what it is between a .243 up to .338 or .35 calibers.
As for myself, which cartridge used (within limits) is much less important to me than the trigger, scope, and stock fit of the rifle. If each of the aforementioned is good, then pick any of the top 50 cartridges, and I am good to go. Yes, I can pick out some I prefer over others, but arguing cartridges is just a way to pass time, not to settle a question.