I always have my eye out for another good Ruger Speed Six .357 in either barrel length, a 3-1/16" .357 SP101 with a particularly good factory trigger, or an SP101 chambered in .22 LR in ANY barrel length. Yes, Rugers with good triggers do exist, if one has patience. So, there is a decent chance my next handgun will be a Ruger revolver, though I am looking more at a couple of rifles lately, so it may be quite a while.
If a good deal on an S&W K-frame chambered in .22 LR comes along, I may decide to go for it. Same for a particularly good pre-key-lock M19.
If I find an available .45 Colt New Frontier with a decent trigger and good lock-up, I will probably try to do what it takes to acquire it. Most I see are quite loose, even if fired very little. Colt had erratic QC for a while.
I also have an interest in a SIG P226, particularly if it has barrels for both .40 and .357 SIG.
I have my eye on a nice pre-owned Freedom Arms Model 97 chambered in .41 mag, at a local dealer. I nearly bought it a while back when it was new, but someone beat me to it. Now, it is back, after a trade; I recognized the distinctive serial number.