I live in a rural area so have a bit of everything handy. My bedside gun is a Springfield XD-45 with light and stoked with 230 gr Remington Golden Sabers. I have my old duty belt on the floor with spare magazines, extra shotgun ammo, light, Mace (I always have a lesser means of defense in case it is called for), and spare cuffs (I'll cuff a downed intruder so to lessen the risk to me if I have to treat family members or guests for wounds). Time permitting, I have either a 20 ga Remington 870 with 23" barrel or an AR-15 to choose from, depending on the necessity. The AR is a Bushmaster Patrolman with a 4 rail forend with a light and pistol grip. I have a Lucid red dot on top which works well at house ranges by treating it as a peep sight if the light is not turned on. I have it loaded with a handful of fully jacketed hollowpoints followed by Trophy Bonded Bear Claws. The former is for coyotes and such and two legged varmints as they may be out in the open initially. The Bear Claws are to give a little more penetration if needed. The 20 ga is a 1970s model which was built on the 12 ga frame. This gives it plenty of extra weight to soften the recoil making it easier for my wife to handle if need be.
I picked a 20 ga rather than a 12 as my wife finds it easier to use as well as to compliment her shotgun choice, a 20 ga Beretta 390. She is a Class A sporting clays shooter and her gun of choice is a 12 ga 391. As the two guns operate and have the controls in the same places, it is a simple switch for her. The 20 has a 24" barrel which is a better choice indoors than the 30" barrel of her 12 ga. She also absconded with my M1 Carbine which is her rifle platform. 110 gr soft points will do a number on whatever she needs to shoot. She is also looking hard at a Beretta CX4, I hope she picks it as I can then get my M1 back. She has no preference but I wouldn't mind 40 S&W as it would give a bit more reach than the 45 ACP and a bit more punch than the 9mm at a distance. I also have plenty of ammo/components for that cartridge which is a plus. Her handgun is my old S&W 66 with 125 gr Federal Nyclads in 38 Spl +P. They are far out of production but they are one of the better 38 Spl loads ever in my opinion. I have no doubt they will still work and, if not, she is well insured.
I also have a PolyTech M-14 copy on hand for larger intruders such as black bears. I like the magazine feature as it is fast to make ready. The shotgun slugs would handle a bear at close ranges but if I had to reach out to one around the barnyard, the M-14 would be my choice. I first used a Remington M-81 in 300 Savage for such chores but it was a pain to load even with stripper clips. The box magazine is much nicer and easier to use.
Outside we have taken several steps to prevent ever having to reach the point of defending ourselves. Good, secure house construction, fences, motion detectors/lights, dogs, farm animals, and an alarm system are just a few of the measures I adopted for my home. When I first moved to the area, meth was just becoming a problem and labs were beginning to crop up locally. I take a dim view of such activities and I quickly hardened my home. It took several years and a few run ins before cooking operators moved to more hospitable climes.