Unique is a versatility champ. I have not found better in the 44 Special and 45 LC in handguns. I have tried 2400 in both cases, and to get the accuracy I want, I have to push the velocities at the upper end, and I don't want that. Not sure the pressures are appropriate for N frame S&W's.
But Unique, in these two cartridges, with 240 grain in the 44 Special, or 250's in the 45 LC, the accuracy at 850 fps with either cartridge is outstanding. And consistent, shot my loads hot and cold.
If you are trying to shoot a rifle, I am sure you will get better velocities with the 2400. Of the magnum powders that I have tried, 2400 is the most flexible. I have shot very accurate and powerful 44 Magnum loads with a 240 grain bullet, with 17.5 grains 2400 and the classic Keith of 22 grains 2400. H110/W296 is a powder that you cannot cut the charges, don't know why, because I stuck to the manufacturer advice. Don't want to experience a Kaboom as part of the learning curve.
I think Unique is the second oldest powder on the market, probably dates to 1899 or something. It has stuck around because of its flexibility in so many pistol cartridges. It is not the best for low end velocities, Bullseye is better for target loads, and it is not the best for magnum loads, 2400 does better. But it works well low and high, and is outstanding in the middle.
I am slowly getting down to three powders: Bullseye Pistol for 32 S&W L, 38 Special and 45 ACP. I have excellent loads in the 38 Special with Unique. Unique for 44 Special and 45 LC, and 2400 for magnum loads in the 357 and 44 Mag. I have excellent loads in the 9mm with Bullseye Pistol, developed some with Unique. The recommended powder for 9mm is Power Pistol, which is, as I understand, a different pressure curve Bullseye Pistol. They can blend the stuff however they want. The recommendation is based on getting the 9mm bullet up to 1200 fps for 50 yard accuracy. This is one reason the 9mm sort of disappeared from Bullseye Pistol Competition, there was no massive recoil advantage as the cartridge has to be pushed for 50 yards. And, it has strange recoil characteristics that shooters have to get used to. So, while the recoil is less, it is not that much less, and it is sharper, and the pistol twists around different.