The only thing on this continent I wouldn't go after with a .30-06 with is a Grizzly, and then I'd prefer a .45-70 or a 12 gauge slug gun. Aside from that, it can do anything you need to. You can load it with real light loads for varmints and new shooters, real heavy stuff for moose, and standard M2 ball in your M1 Garand for a somewhat obsolete (oh I just opened Pandora's box, yes my AR is lighter and yes I recognize the M1 is a better baseball bat, and yes it does hit harder, calm down) BUT STILL VERY GOOD, LET DOWN YE PITCH FORK AND DOWSE YE TORCH combat rifle. There are somewhat more optimized rounds for some tasks out there (it just isn't an extreme-range precision cartridge, and it isn't as good varmint or small-game round as some others out there) but it'll put people, deer, hogs, black bears and similarly sized adversaries down more efficiently than any other non-wildcat cartridge out there (though .308 Winchester is right there with the .30-06).