A guy on another forum that spends about 1/2 of his year in Alaska flying his little private planes into remote areas went through this exercise a few years back and ended up with an HK USP 45 and uses .45 Super in the gun.
He tried big revolvers, and didn't like the weight, and limited capacity.
He tried Glock's in 10mm and .45 Auto, since he was shooting competition Glock's and wanted them to work, but found the big bullets he wanted to use in 10mm and .45 Auto didn't feed particularly well in the Glock's.
The HK USP 45 gave him the capacity, durability, and reliability that was lacking in his other options.
However, in the ensuing years, those odd, all copper bulllets like the Lehigh Defense offerings
https://wilsoncombat.com/40-s-w-115gr-lehigh-defense-xd-20-box.html
seem to have opened up other options in guns and calibers in his mind. They feed well, and he's found they do a good job of reliably penetrating large bear skulls, his personal requirement for this tool.
This handgun is a backup tool for him. When concerned about bears, his tool of choice is a shotgun with slugs.