NICE!
Relatively light rifle, short barrel and short ranges would suggest the following:
No need for a 500 grs monster, so a good 300+ grs bullet that will feed well in a lever action. My recommendation would be:
RCBS 82045 - 325 grs plain base, order with SPG (black powder) lube, sized .458"
https://www.montanabulletworks.com/product/45-rcbs-82045-325gr-fn-universal/
or, Lyman 457191- 292 - plain base with SPG lube .458"
https://www.montanabulletworks.com/product/45-lyman-457191-292gr-fn-bb/
Using large pistol primers (BP very easy to ignite) load 2FFg (I like Olde Eynsford for consistency) so that with 1/8" compression of the powder (can be done with a dowel (marked for depth) pressing on a .460" ca rd wad - or for better consistency, Buffalo Arms has an adjustable powder compression die) there is just enough room for a dollop - a ball in size between a pepper corn and a dried pea, for example - of BP lube, then another .460" card wad and the bullet seated on top of that so that there is no space between bullet, card and powder etc. A taper crimp that takes the bell out of the case mouth but doesn't deform the bullet base in any way will be best.
This is a good place to start. For best accuracy, you may adjust seating depth a bit, and play with compression. Tips: Don't over compress powder and don't use bullet seating to achieve compression. Ideally, the bullet would virtually hand seat under slight pressure and come to rest on the top card wad at the desired seating depth. In reality, a little pressure to final seating depth is normal but too much pressure can deform the bullet. Don't get too focused on powder. You will hear it must be done by volume not weight. This is not true when using the same powder. A volume throw, like a Lee Dipper is fine, but try to get it consistent in scooping. One way to do this is to take several scoops of powder, attempting to be consistent in how much you scoop. Weigh them to see if you are consistent. Unlike smokeless, a couple of grains either way per throw doesn't really matter. More than four grains, work on consistency.
It's awesome that you are going to shoot yotes with BP in this rifle! Good luck and enjoy!