I have a S&W 25 45colt Mountain Gun, a Ruger Vaquero 45colt (older model) with a 45acp cylinder to go with it, and a BFR 454. I have owned a New Vaquero 45colt, a Ruger Redhawk 4" 45colt, and a S&W 25-5 45colt. I carry the Double Tap 335gr loads you mention in my Ruger when I go bear hunting. I would never attempt to shoot them in any S&W. They exceed the recoil and blast of any standard 44mag round I have fired, and are a handful. I regularly push 255-270 grain bullets to 950-1000 fps in the S&W, and am confident that those reloads are stout enough to handle anything I encounter in the woods of Vermont. The Double Tap stuff great, but it is approaching 454 levels. If you want to push stuff like that thru a double action revolver, I recommend you get a Ruger Redhawk.
I have no experience with the Anaconda, but with loads that robust, and with bullets that heavy the "overbuilt" qualities of a Ruger begin to make shine. I have to admit that I seldom shoot my 454 casull, and unless I was looking to increase the distance I was hunting at with a revolver I don't think all the noise and recoil is necessary. A 265gr LSWC moving at 950fps will go straight thru a 200lb deer lengthwise (I've seen it). Pushing the projectile past 1150fps usually leads to more tissue damage, but no quicker or more reliable kills. If I were going for brown bear or grizzly, I'd want the 454, but for black bear, moose, or deer within 50-75 yards I think you'll find that 850-900fps at the target (not the muzzle) will get the job done and leave your ears and carpal tunnels intact.
On a similar note, my brother has a 500 S&Wmag BFR, and we reloaded some rounds for it this weekend. We did some light loads with a 440gr LFN with a really broad meplat (looks just like the Double Tap stuff) pushing 1100 fps for plinking. The recoil was similar to a 44mag or heavy 45colt. We also loaded some Ranger Rick 700gr LFP rounds that look like a beer can sticking out of the end of the case. With 27.3gr of LilGun they chrono'ed at 1250fps, and the recoil was really painful. I think we could push them faster, but why bother. They cut a clean hole thru 20" logs we were using for a backstop, and create a two and a half foot deep clean tunnel when fired down into hard soil. My brother loves them. I think they're absurd, and would only be practical on big bear, rhino, elephant, or cape buffalo.
Going back to the 45colt, the Double Tap and Buffalo Bore stuff is actually 45magnum ammo. A S&W N-frame 45caliber revolver is a beautiful thing, in my opinion. I have a 22-4 4" 45acp S&W that I load 255gr lswc's at 950fps for. It is the equal of the 45colt Mountain Gun, and either one easily passes as my favorite handgun of all time. But they are not 45magnums. I suspect the Anaconda falls into the same category. The S&W's and Colts might do okay with the heavy loads for a while, but until you fire heavy projectiles at these velocities it's hard to appreciate the wear and tear it puts on the gun. I've had ejector rod housing screws shear off, front sights break off, and grips crack due to the recoil of heavy 45colt and 454 casull loads in lighter guns. You may not like Ruger's, but if you like the heavy loads and plan to shoot them a lot you would be wise to go with a Redhawk, Blackhawk, or older Vaquero (or a Freedom Arms or BFR for the really heavy stuff).
Good luck, and let us know what you decide/get.
Hastings