These threads always generate posts where people list the round they carry but don't list the reason why.
I think to go about selecting a cartridge. you have to gain an understanding or at least form a belief about what causes incapacitation. After that it is a matter of what part of the bell curve you want to cover. On one end of the spectrum is a frontal shot on the skinny guy wearing a T-shirt. The skinny guy is 11" from front to back - not much muscle, a frontal shot with a 105gr EFMG that penetrates 8" to 9" is going to reach vital tissue, a frontal shot with a 115gr all-copper hollow point that penetrates 10" to 11" is going to reach vital tissue. On the other end of the bell curve is having to take a cross shot on a barrel-chested, muscle-bound thug wearing a jean jacket over a shirt, and a T-shirt underneath that. Can those same rounds go through a jean jacket, a shirt, a T-shirt, a bicep, another layer of T-shirt, another layer of shirt, another layer of jean jacket, another layer of jean jacket, another layer of shirt, another layer of T-shirt and still reach vital organs?
Probably not.
But maybe you think your odds of facing a barrel-chested muscle bound thug are too slim to go through all the trouble of preparing for such an encounter. Or maybe you think that once a barrel-chested muscle bound thug sees that you have a gun he's gonna high-tail it out of there.
Maybe another way to approach it is to go by reputation or anecdotes - for example the Federal 9BPLE 115gr +P+ round developed a good reputation with the Illinois State Police.
But there has to be some logic behind the selection process.