I would not use any of Elmer Keith's loads in vintage 44 Spls or 45 ACP's.
I tried one of his loads in a M1917 revolver, the recoil was horrible and I am certain a steady diet of the things would beat the thing to death.
Older, pre WWII revolvers, you find many that were never heat treated. Frames so soft you can easily bend them.
Do not use any Elmer Keith loads in Charter Arms Bulldogs. The first production year gunwriters were using Elmer Keith loads in these lightweight pistols. Check out the article by Major George Nonte in the 1975 Gun Digest. He actually loaded a 250 Keith Bullet with 17.5 grains 2400, thought that had too much recoil (duh!)
then shot a bunch of 250’s with 7.5 to 8.0 grains Unique.
The first load is now considered 44 Magnum level, the second are hot in a N frame. Firing these mini nukes in a light frame Bulldog, I am personally amazed the top strap did not come off!.
I will bet a number of top straps came off Bulldogs from owners who copied Nonte's loads.
When you get into later model pistols, it all depends on the pistol. I have shot the 240 LSWC in a M624, found the recoil objectionable and shelved that idea. Shot in Ruger 44 Magnums and it was a powerful load but not horrible in those heavier pistols.
As much as we all like Elmer Keith, the guy did was not using instrumentation, just logic, in developing his loads. If the gun did not blow apart, he shot it.
I cannot fault his 240/250 grain 22.0 grains 2400 in the 44 Magnum. It is an outstanding load.