Not sure if by "western" you mean the western movie type belt rig with the holster hanging from a slot in the bottom of the belt. Great for fast draw, not so great for day in, day out carry. The gun gets in the way more and flops and bangs around more than when carried higher and tighter to your body.
Ive carried both cross draw and strong side. I much prefer strong side at about 3:30-4:00. Cross draw seems to be in the way more often, and bangs the gun into things more. If its far enough forward it also limits getting into your left front pocket, which is where I carry my keys and pocket knife. Nuisance.
Strong side with a Threepersons type holster keeps the gun mostly out of the way yet very easy to get to and draw quickly. They don't push the gun up in chairs or vehicle seats for me, and the gun doesn't seem to get as banged up. For field use I attach mine to a plain cartridge belt. No fumbling around with the holster falling off the belt or moving when putting on or taking off. I tend to hang it from a hook by the buckle also, and the holster doesn't fall off the belt then.
A 4" Smith 29 or 4 5/8" Ruger SA carries nicely all day with a decent holster and belt. Ive forgotten I have it on many many times after wearing it all day. Hiking or hunting, cutting firewood with the chainsaw or loading lumber at the sawmill don't cause problems for me when carrying. A 6" 29 still carries well, but I get a little more interference from chairs and vehicle seats. Nothing that would influence me to do crossdraw though. As for "big revolvers", Ive had a number of longer barreled pistols, many ended up traded off or cut down, I usually don't like carrying them compared to a 4" Smith or 4 5/8" Ruger SA, so they see little use.
I also have an 1890s style Miles City style holster for a Ruger SA. It doesn't have a strap or hammer loop, but the gun is tight enough it wont shake out easily if turned upside down. It carries nicely similar to a decent Threepersons. Its carried on a plain cartridge belt.
