As long as both loads are on the same vertical plane it should work . the base sight in ranges will be different though . Leupold can make dials with ballistic ranges starting from different ranges , my .280 has a base setting of 250 yards and goes out to 750 , so i have a point blank range of about 275 yards before i would need to dial in . So if you zero in for one or the other , then figure what range the other is set to zero at , they should be able to make you a turret based on that load , too . But only one would have a 100 yard zero , the other would be at whatever range it happens to zero at . You would just have to make sure you had it set to your starting range when you change turrets though .