I have three Bond Arms frames, one that came with the Snake Slayer IV barrel, one that came with the .45 ACP barrel, and one that came with the .45 Colt/2.5" .410 shotshell barrel. I have several other barrels, including the .22 LR, .327 Federal, and .357 Magnum. The .22 barrel is lots of fun and an easy way to smooth out the action. The trigger improves a lot after 500 rounds. I really like the guns for what they are. I remember what they are not -- namely fast into action.
For defense, one is better of with a J-frame, but the Bond derringer makes a good snake gun and a good SASS side-match gun.