You don't need or want hot .45 Colt loads for defense against people.
Overpowered, unnecessary, the standard .45 Colt stuff with a good bullet more than does the job.
I deliberately said the hot .45 is not pleasant for MOST people, because I knew somebody'd jump on & say they do it all the time & love it.
There are also people who enjoy hitting themselves in the head with a hammer, but they don't constitute the majority.
I've worked with hot .45s through Rugers, both single & double action, in both Red & Black, and I've worked with .460 & .454 Casull, so I do have a frame of reference.
I did not enjoy the Mammoth-Killers in .45 Colt through the round-butt Red.
Even with a bigger Hogue grip installed.
I'm not knocking the Pain Junkies (term used affectionately & with the utmost respect
), but if you don't NEED the extra power & expense to put a BIG animal down, either hunting or defensively, you probably don't want the hot .45.
Standard .45 will do against a deer-sized critter out to 35 yards just as well, the key there isn't the "magnum" .45, it's the ability of the GUN & user to deliver.
The hot .45 stuff isn't necessarily any more accurate at that distance & standard has all the power you'd need, again with an appropriate bullet.
Denis