You would have to shoot it to find out. A couple of things to think about, especially noticable with longer barrels revolvers.
A firearm begins its recoil while the bullet is in gun because of the equal and opposite reaction of the bullet/gun relationship. This causes the barrel to be tipped upward at the muzzle as the bullet leaves the bore.
- Heavy bullets tend to shoot higher than lighter ones because of greater recoil.
- Slower bullets tend to shoot higher than same weight faster ones because of the bullet's longer "dwell" time in the barrel. More time for barrel to move under effects of recoil while the bullet is still in the bore.
- Slower, heavier bullets tend to shoot higher.
- The Buffalo Bore load you are going to shoot is a much heavier bullet (shoots higher), greater recoil (shoots higher) but is considerable faster (shoots lower).
I'd say it would shoot higher.