I owned several Sigs for years inlcuding the P226 and P220.Unless you know a Sig gunsmith who can do a fine Sig trigger action job on it, you won't shoot it to its full potential. And most Sig owners don't even think about a trigger job for their Sig. So you'll need to spend a $100 at least to get that done.
I consider them both to be excellent weapons for duty carry, competition, and range training. However, for civilian CCW where IWB is the standard for carry, the P220 is a challenge due to its exposed hammer spur. Caught my love handle way too many times.
And more than a few people including myself reported rust spots on our Sigs. Even after I breakFreed it faithfully and regularly. So I'd recommend hard chroming at least the slide or some other metal treatment. Another $120. Several broken trigger springs with my P220 and that was it. Sold them both.
For an all around jack of all trades 45 ACP, I'd recommend the Glock 21 or the Glock 30 is you like a smaller more compact version. I've also owned both and prefer the G21 for all around work including winter carry with some 230 grain Hydrashoks or 185 grain +P Rem Golden Sabres to bring on the heat.
And since you already are familiar with the Glock system, you don't have to adapt.
But skip the Glock 36, great only for CCW but with the low cap and think backstrap, it recoils harder than my Glock 32 in 357 sig. Mixed reviews on that one even at GT.
If you go with the Sig P220 or P245(chopped P220 that is super glued to my gun shop cases), you 'll have to adapt to a DA/SA trigger pull. Didn't many law enforcement agencies move from Sig to Glock? Was not just cost.
The FBI Academy Firearms Instructors used to teach grounding your first DA shot to get to single action for better accuracy. Mastering that first DA shot from a Sig is just as difficult as from a SW revolver. Another reason why agencies moved from revolvers and that DA pull.
When you shoot the P220 and G21 side by side, you find that the Sig is just a tad more accurate at 25 yards in single action, but that it recoils more.
Thus, you can get tighter groups with the Glock due to less recoil but for target shooting, slow fire, the P220 may get you better accuracy.
Right out of the box, the Glock offers a reliable, durable, so what if it scrathes, accurate gun. The Sig needs some work. Sweet but not as versatile.
Had them all and I carry the Glock 21 when I don't think the Glock 20 in 10mm is warranted.