Over the past 8 years, I've gone through 28 different handguns trying to find what was "right" for me. I've owned pistols and revolvers by S&W, Colt, Taurus, Dan Wesson, Walther, H&K, Detonics, CZ, and Glock.
They used to joke about me at the local guns store that I never BOUGHT a pistol there, but I'd RENTED quite a few.
Looking back on it, there's 2 I kept coming back to time and time again. The 1911 and a 4" .357 Magnum revolver. My collection just felt incomplete the few times that I was without them.
Presently, those niches are filled in the collection by a Springfield Armory Mil-Spec that I built up to how I wanted it, and a stock S&W Model 28 4" revolver. I'm also planning on picking up an SA 4" GI Commander version and building it up to match my Mil-Spec. That'll replace the Mil-Spec as my carry gun.