I don't want to be disrespectful, or off topic for this thread, but I want to address this specific area.
A defensive handgun should only be used when there is an immediate and serious threat to human life. So yes, you shoot through glass if that is the most effective way to protect human life. If you believe that your rounds will not penetrate the heavy glass, or that you cannot make an effective hit though the glass, then you might take a different shot. But if you are still concerned about damage to the windshield, then it is probably not time to shoot yet.
I can imagine situations where rolling down the window or opening the door would be good strategies, but those situations are very unlikely. In most such situations, trying to drive the car would be better. If you are boxed in, but can escape by damaging your car or nearby inanimate objects, that is likely to be an overall win.
And now, back to your previous channel about administrative handling of handguns. This thread so far has been interesting.