The only advantage to shooting a .270 Win over some other cartridges, especially if you're only going to kill things beyond 300 yards, is that, if you handload, you can load 90 grain bullets for enjoyable target practice or varmint disposal. My "super-accurate" load with 90 grain bullets is 48.5 grains of IMR 4895, CCI 200 primers, Rem cases. At 100 yards, in my rifle, it shoots very close to my hot, 130 grain deer load, but without the recoil and muzzle blast of a standard load. Using it, I've won a few turkey shoots, including a "running" deer shoot in the woods. (That's another funny story, but I'll spare you.)
Weird event: One day, when going deer hunting, I had two boxes of ammo in the truck and grabbed the wrong one, and in a hurry to load up and get out there, didn't notice that I loaded the rifle with the (under-powered) 90 grain "target" ammo. I hurried out to my stand along a woods road and sat down on my stool. After a few minutes, I pulled out my deer call and gave it a few toots.
After a few minutes, I heard a deer walking toward me on a deer trail to my right. Then the small buck came into view, about 45 yards away, presenting a nice broadside view. I fired and the deer stepped behind some low cedars, but kept walking toward me. I told myself that it was definitely hit in the boiler room, so let it keep coming. If it makes it to the road, shoot again. The deer kept walking toward the road and just as its nose entered the opening, it dropped dead...only about 20 feet from me!
I wouldn't use that bullet for deer on-purpose, but it was a really memorable event and a story I've told to friends.