Short version: I love .357 revolvers, and am comfortable carrying them for defensive purposes. I especially favor the GP100, and have several of them.
Longer version; may well cause the reader to fall asleep: I started handgunning with a 1911, in late 1982 or early 1983, but by late late 1983, had to learn DA sixgunning, in a police academy. The S&W L-Frame was the standard revolver, during the academy, with a few exceptions granted to cadets who already owned a different S&W, Ruger, or Colt .357 DA revolver. After graduation, rookies had to use only DA revolvers, for defense of self or others, 24/7/365, during the first year of service. Wanting to survive my rookie year, I made a diligent effort to learn the DA trigger stroke. To this day, I can shoot a long-stroke DA trigger more consistently than any other handgun trigger.
During the above-mentioned academy, I had ordered a Model 686, from a local LE-oriented S&W dealer, who would deliver the revolvers to the academy, right before firearms training began. I also bought a Model 581, from a home-town dealer, but cannot remember whether I did so before starting the academy. So, I am unsure which was my first .357 revolver, but I think I had the 581 before the 686 was delivered.
No handgun fits my hands as well as a GP100, with the original-pattern factory grip. S&W K/L revolvers, and Ruger Speed and Security Sixes, fit me as well, with suitable grips. I bought my first GP100 about 1991.
I went through a big-bore revolver phase, in the Eighties. By 1990, I realized that N-Frames were too big for my hands, and that I was wrecking my right thumb and wrist with the ergonomically-improper “h-grip,” in an effort to get enough finger on the trigger. So, I backed-down to revolvers that fit. I also became comfortable with the concept that one does not need to use big bores to disable a human opponent.
One night in June 1993, I used a GP100, to fire the one 125-grain .357 needed to devastatingly disable a human attacker. Some officers up-gun after a defensive shooting incident. I did not, as my ammunition had performed well. (I did switch to a .45 ACP autoloading duty handgun in 1997, for reasons unrelated to my defensive shooting incident.)
When it suits me, I carry a Glock, loaded with 9mm +P Gold Dots that are not so far different from today’s defensive .357 Magnum ammo. When it suits me, I carry a revolver, often a GP100. I shoot a GP100 more accurately, so, a deciding factor, which one to carry, may depend upon the perceived probability of needing to engage at longer distance.