A buddy of mine carries a P250 daily. I offered him one of my 320's in trade to give him an upgrade, whereas I'd just use the 250 as a loaner/demo gun in classes, and he had all of the grip and slide/barrel modules. He fired the 320 a few times and turned down the trade. He's more comfortable carrying a longer trigger, even though a guy like me might see it as a disadvantage... So there ARE those guys out there...
There's a reason it didn't do well, and a reason it's discontinued. The Ruger P345 comes to mind as another flop, although not nearly as recent, and the Sig P224. The Remington pistols flopped for different reasons than the 250, in my opinion.
If I consider the P250's "failure" to be driven by the fact it was a "commercialized prototype," then I could argue the Ruger LCP Gen 1 and LC9 were in the same stroke as the P250 - it didn't take long before people were demanding upgrades and changes, hence the LC380, LC9s, LC9s Pro, LCP Gen 2, LCP Custom, and LCP II. Ruger sold a boat load of the LCP Gen 1's and LC9's, so not many folks would consider them a flop, but there were SO many buyers who were disappointed in these first gen pistols who were very content with the subsequent generations/revisions.