The ammo and magazine choices have already been addressed but here are two modifications to the rifle that I think are worthwhile:
1. Extended magazine catch. I have one of these on my 10/22 and it definitely makes it easier to remove the mag, compared with the factory catch. It does not stick out so far that it would cause unintentional mag drops.
2. Automatic bolt release. This allows you to release the bolt by simply pulling on the charging handle and letting it go, rather than mucking with the awkward factory release. I linked to a Volquartsen but you can modify the factory bolt release with a small half round file, by modifying the larger of the two holes to match the shape shown in the pic at the link. Even though the 10/22 does not have a last round bolt hold open, this mod is very handy on the range.
One word about ammo: In my experience, CCI .22 rimfire is the most reliable when it comes to ignition, not just feeding. In thousands of rounds of CCI .22 LR, Shorts, CBs, and WMR, I have had exactly one dud. I can't say that for any other brand of .22 rimfire ammo manufactured in the past 15 years.
Also, this probably isn't applicable to Byron, but for any southpaws, if you're using a 10/22 for defense Volquartsen sells a left handed safety conversion that's not too hard to install after you watch a Youtube video on takedown/reassembly of the trigger group. I added one to mine and it makes the rifle more ergonomic for us lefties.