I would pass that shot with any gun I own. Shooting through branches with ANY caliber is much less ethical than using a .223, or a 22-250, or a .243, or a 6mm, or a 25-06.The question becomes if you stumble across a once in a lifetime buck who decides not to give you anything other than a quartering shot, perhaps through some branches, and no time to get a rest, do you think your odds are as good as with something bigger? Will you pass or try to make a perfect shot ? Perfect shots happen mostly on forums BTW. And, whatever you do will you regret not getting the deer if the caliber decision played a part in it ?