anecdotal evidence says that stingers will crack the slide. otoh, the gun is best viewed as a consumable anyway. it's not built to last.
i feed my p22 100% remington golden bullets (and minimags when i've got them to burn, but i ain't payin that much to feed a p22). federal does not reliably cycle the action or feed properly. winchester is slightly less reliable than remington, but will lead the barrel (they really need to plate their bulk stuff).
the gun is very light; me, i need some weight if i'm going to even pretend to shoot well. the 3.4" barrel makes for surprisingly loud shooting for a p22. the 5" may be quieter, but it's said to be no more accurate, it costs more, and it's harder to take down.
p22s are sensitive to proper lubrication. do not under oil, do not over oil. if they are left too wet, oil will leak out all over the frame and slide, and the safety may walk loose.
the lack of a captive recoil spring is mystifying; the fact that the reassembly rod that came with mine was the wrong diameter is infuriating.
the mag release is in perhaps the worst location ever concieved; you *will* eject the magazine during the course of normal operation unless you are conscious of the issue.
the plus side of the p22 is that it has the best grip size i've ever seen for medium hands and below. women and kids tend to love them. that's why i own one. however, owning the p22 is the reason i bought a 22 revolver... i wanted something more satisfying to shoot.