Do we know of evidence against Holder specifically? My understanding is that it's the lawyers at the ATF who have been running things there for years. The revolving door in the directors office is just for the stooge to catch all the political flak for the actions of the Office of Legal Council to the ATF, and the FBI lawyers who work with them.
There is certainly truth to this. My wife sat on a local board and the staff (with whom she had cordial relations) were frank about saying "we'll be here when you're gone."
Holder is a hard core left wing ideologue. He says things that the President doesn't agree with, or at least, doesn't want him to say out loud. He was told to shut up about guns back in the first year of the Obama presidency, and he may be told again. He also seems to be a mediocre administrator at best.