The Beretta 84FS Cheetah.
All metal frame, double stack magazine (13+1 capacity), double action/single action, frame-mounted thumb safety/decocker, just about as big as a .380 pistol gets. It's the perfect compliment to a Beretta 92FS, which is just about as big as a 9mm pistol gets. Beretta has a tendency to over-build their pistols for their intended caliber. But they are extremely reliable, last forever, and their size and weight help to mitigate recoil.
As far as a personal defense gun - 14 rounds of modern, quality, high velocity .380 hollowpoint ammunition out of a 4" barrel is nothing to sneeze at.