I'm an attorney and there are different ways I've used, but I'm new at this and still learning.
For the most part, I take my 642 and pocket carry it all day. I've tried an ankle holster and just don't like it.
This winter, I've been able to carry my Kimber Ultra Carry in a high ride belt holster when I wear a fleece jacket or sweater in the office to cover it. That's my favorite way to ccw when the weather is right (and here in Florida, it doesn't get all that cold all that often). A couple of times, just for giggles, I've been able to conceal/carry my 625 N Frame revolver the same way.
But most of the time, I pocket carry my 642 and place it in my desk when I'm sitting down. During the summer, that will probably be the only way I'll be able to CCW at work, so I am already looking at getting another very small carry weapon, like a Ruger LCP or something. But I have to say that, so far, I've been happy with the 642.