Old Dog...and others: Many thanks for taking the time to chime in on my question. It's much appreciated.
And to clarify my original post and respond to Old Dog -- I too am in my mid 70's and have accumulated this "collection" over a whole bunch of years. (I got the 2 EZs in anticipation of aging hands, although I have 0 need for them presently).
The genesis of my question is that I am perfectly comfortable carrying any of the listed pistold. I have and do carry all of them. But I do have a few preferences, but here's where the confusion comes in. My "best" carry gun is the PX4 compact in 9mm. Had it worked over (and they did a great job) by Langdon and added a laser. It carries small, trigger is outstanding, fits like a glove, has a whole bunch of bullets, and I shoot it well.
But, I "know?" .40 and .45 have more stopping power, so I sometimes get a nagging feeling I should carry a bigger-than-9mm-bullet. Although my research shows 9 is more than adequate for my needs.
I love my 3rd gen S&Ws, I won't carry my Walthers as they are too valuable to get caught up in the legal system should (god forbid) I ever have to use them; the P6 is just a tad too big/too heavy for comfort, the P99s have great triggers and the anti-stress & decocker make 'em perfect for carry, and the 250 in either 40 or 9 is outstanding trigger-wise and very safe as it's DAO.
I know I should sell some of what I have, as I "should" focus on getting better with fewer guns for self-defense, but I am loathe to part with any of them.
I just thought I'd ask around and see what folks thought.
(And just to confuse the issue, I have an M&P in .45 and a Smith 3953 [DAO] inbound as I wanted a .45 in striker and liked a Smith 4046 DAO trigger so much when a member of the Smith forum offered me a DAO in 9 I couldn't say no, so sold off a Canik TP9SP Elite to pay for it.
Again, thanks for your time and knowledge.