I have a Colt Python, a Ruger Super Blackhawk, and a S&W 500 (357,44, 500) I've shot a LOT of hogs, some bear and been to Africa four times. (one Cape Buffalo, one elephant, one stink bull giraffe and a whole bag of plains game - photos available - I write for African Hunter Magazine).
For North American dangerous game smaller than Brown Bear, use the .44. It won't bust your wrist, even with 300-gr bullets. Get used to it - shoot it a bunch, 250-350 rounds for starters. For Brown Bear,I shoot Ballistic Supply 600-gr. hardened lead bullets in my S&W 500 Mag. I took the giraffe with the 500; 18'6" tall, 2400 lb. +or-.
Hogs go down easy with proper bullet placement, so a 357 or 44 is fine. If you need to shoot through the shoulder plate, go with the 44. I bounced a 300 Win Magnum 180-gr. off a boar's skull on a frontal shot. Bad angle, the bullet just spun off.